These with, with out HIV have comparable monkeypox outcomes, research finds
A brand new research from Germany exhibits no main variations within the scientific image in these with or with out HIV who contract monkeypox. The research, in HIV Drugs, was based mostly on 546 monkeypox circumstances in Germany, which has one of many highest monkeypox case counts in Europe. The research is printed in HIV Drugs.
All sufferers within the research had been males who’ve intercourse with males (MSM), and 46.9% had been dwelling with HIV, largely with a preserved immune system and viral suppression. In males with out HIV, 42.5% had been additionally taking HIV pre-exposure prophylaxis (PrEP) and 10.6% of MSM had no identified HIV an infection or PrEP use. The median age was 39.
The signs and presentation of the virus had been comparable in males each with and with out HIV. No males died, and 4% required hospitalization.
Additionally, a research in The Lancet Baby & Adolescent Well being describes 16 pediatric circumstances of monkeypox in Spain; 4 sufferers had been 4 years outdated or youthful, and the opposite 12 had been ages 13 to 17.
In three of the youthful sufferers the transmission route was by way of family contact with their dad and mom, and in a single affected person the transmission route was unknown. Within the older group, 9 sufferers had been contaminated by way of an outbreak in a tattoo and piercing studio, and three contracted the illness throughout sexual contact.
Not one of the pediatric sufferers required hospitalization.
In different information, the US Facilities for Illness Management and Prevention (CDC) late final week reported 497 extra monkeypox circumstances, elevating the nationwide complete to 19,962.
Sep 4 HIV Med research
Sep 1 Lancet Baby Adolesc Well being research
Sep 2 CDC replace
Yellow fever circumstances enhance in Africa, WHO says
Although yellow fever is endemic in Africa, the scenario has intensified for the reason that finish of 2021, with 12 international locations reporting possible or confirmed circumstances, the World Well being Group (WHO) stated in a Sep 2 replace. It added that ongoing advanced transmission has led to 184 confirmed circumstances, 274 possible circumstances, and 21 deaths from Jan 1, 2021, to Aug 26, 2022.
Of 9 international locations that reported circumstances in 2021, six proceed to report confirmed circumstances in 2022. One of many main sizzling spots is Ghana, which reported 33% of all confirmed circumstances. This yr, Kenya and Uganda have been added to the checklist of nations reporting confirmed circumstances. Most circumstances contain individuals aged 30 or youthful.
The WHO stated extra circumstances are anticipated as Africa enters the season when circumstances sometimes rise. It stated the chance on the regional stage is excessive, amid considerations about suboptimal immunization protection in many of the affected international locations. The WHO stated routine childhood vaccination for yellow fever in 2021 was 47%, a lot decrease than the 80% threshold wanted to confer inhabitants immunity. Protection in affected international locations ranges from 7% in Kenya to 94% in Ghana.
Many international locations experiencing yellow fever circumstances are grappling with different well being threats and instability, which contributes to delays in prognosis and surveillance. The WHO famous that the worldwide danger is low and that no exported circumstances have been reported since January 2021.
Sep 2 WHO yellow fever replace
WHO prequalifies GSK malaria vaccine
GSK at this time introduced that the WHO has prequalified its RTS,S/AS01 (Mosquirix) vaccine, the primary for a malaria vaccine and a key step that paves the way in which for the vaccine to distributed to international locations which have reasonable to excessive Plasmodium falciparum malaria transmission.
The WHO prequalification is obligatory for United Nations organizations equivalent to UNICEF to purchase vaccine in partnership with Gavi, the Vaccine Alliance. Prequalification is a rigorous regulatory course of that assesses scientific, security, and technical knowledge to make sure that the vaccine meets preset requirements and is suitable for the goal inhabitants.
Thomas Breuer, GSK’s chief world well being officer, stated that so way over 1 million youngsters in Ghana, Kenya, and Malawi have had not less than one dose of the vaccine, donated by GSK by way of the Malaria Vaccine Implementation Programme. He added that the WHO prequalification paves the way in which for extra youngsters to learn from the vaccine.
A WHO-led pilot program was first launched in Malawi in 2019, which confirmed that the vaccine was protected and possible. In October 2021, this system was expanded to extra moderate- and high-risk international locations. The vaccine is given on a four-dose schedule that begins at 5 months and continues by way of age 2.
Sep 6 GSK assertion
